Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases
نویسندگان
چکیده
منابع مشابه
Infliximab in recalcitrant generalized pustular arthropatic psoriasis.
Generalized pustular psoriasis is an unstable inflammatory type of psoriasis, with widespread areas of erythema and sterile pustules, associated with fever and systemic symptoms. Infliximab is a monoclonal antibody with anti-TNFalpha activity, approved for use in psoriasis. We describe a male patient with a long history of stable arthropathic psoriasis, hospitalized with a generalized pustular ...
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was stable, his skin became irritable and hot with extensive reddening. Though in bed in a warm room he felt cold. During the next three days the skin became tender, and large areas of pustulation developed. Subsequently there was widespread peeling of the skin, and crusting developed on the face and neck. On admission to hospital there was generalized cutaneous erythema and scleral jaundice. T...
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Acquisition, analysis, or interpretation of data: All authors. Drafting of the manuscript: Sanlorenzo, Vujic, Cleaver, Ortiz-Urda. Critical revision of the manuscript for important intellectual content: Sanlorenzo, Vujic, Posch, Quaglino, Ortiz-Urda. Statistical analysis: Sanlorenzo. Obtained funding: Ortiz-Urda. Administrative, technical, or material support: Vujic, Cleaver, Ortiz-Urda. Study ...
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BACKGROUND Palmoplantar pustular psoriasis is often recalcitrant to therapy. Here we evaluated the therapeutic effect of alitretinoin in patients with recalcitrant palmoplantar pustular psoriasis and investigated subsequent immunopathological alterations. METHODS Seven patients with palmoplantar pustular psoriasis were treated with oral alitretinoin 30 mg once daily for 12 weeks. Efficacy was...
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Generalized pustulous psoriasis is a rare type of psoriasis first described in 1910 by Von Zumbusch. This disease tends to have a more benign development in children when compared to its development in adults. However, in its serious form it may represent a risk to the patient's life. Maybe, due to being such a rare disease no therapeutic option has so far consistently proved to be both effecti...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2020
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2020.07.001